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LabMedMolGe - Team

Domenico Memoli

Domenico Memoli

e-mail: dmemoli@unisa.it

 

Laurea in: Informatica cum laude, Univeristà degli Studi di Salerno (2013).

Formazione di esperti nell'identificazione e nello sviluppo di nuovi bersagli molecolari per la diagnosi, la prognosi e il trattamento dell'ischemia cerebrale e I tumori plurifarmacoresistenti della testa, del collo e della mammella. PON03PE_00146_1 (2014-2015)

Dottorato in: Medicina Molecolare e Biotecnologie Mediche (2019)

Post- Doc fellowship "Innovazioni diagnostiche e terapeutiche per tumori neuroendocrini ed endocrini - RARE-PALT-NET"

Competenze ed attività di ricerca: Esperto in Bioinformatica. Analisi di dati da esperimenti di Next-Generation-Sequencing (RNA-Seq, ChIP-Seq, smallRNA-Seq, RIP-Seq, RRBS, Exome). Mantenimento della struttura computazionale del laboratorio.

Pubblicazioni:

  • Ferravante, C., Memoli, D*., Palumbo, D., Ciaramella, P., Di Loria, A., D’Agostino, Y., Nassa, G., Rizzo, F., Tarallo, R., Weisz, A. & Giurato, G. HOME-BIO (sHOtgun MEtagenomic analysis of BIOlogical entities): a specific and exhaustive pipeline for handling metagenomic shotgun sequencing data. BMC Bioinformatics. 2020 In revision. *co-first.
  • Ricciardi L, Giurato G, Memoli D, Pietrafesa M, Dal Col J, Salvato I, Nigro A, Vatrella A, Caramori G, Casolaro V and Stellato C. Posttranscriptional gene regulatory networks in chronic airway inflammatory diseases: in silico mapping of RNA-binding protein expression in airway epithelium. Frontiers. ACCEPTED
  • Sellitto A, D’Agostino Y, Alexadrova E, Lamberti J, Pecoraro G, Memoli D, Rocco D, Coviello E, Giurato G, Nassa G, Tarallo R, Weisz A, Rizzo F. Insights into the  role of Estrogen Receptor Beta in Triple Negative Breast Cancer. Cancers. 2020 Jun 5;12(6):1477. doi: 10.3390/cancers12061477.
  • Alexandrova E, Lamberti J, Saggese P, Pecoraro G, Memoli D, Cappa VM, Ravo M, Iorio R, Tarallo R, Rizzo F, Collina F, Cantile M, Bonito MD, Botti G, Nassa G, Weisz A, Giurato G. Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer. Cells. 2020 Apr 3;9(4):E874. doi: 10.3390/cells9040874. PMID: 32260128.
  • Trino S, Zoppoli P, Carella AM, Laurenzana I, Weisz A, Memoli D, Calice G, La Rocca F, Simeon V, Savino L, Del Vecchio L, Musto P, Caivano A, De Luca L. DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation. Stem Cell Res Ther. 2019 May 20;10(1):138. doi: 10.1186/s13287-019-1245-6. PubMed PMID: 31109375; PubMed Central PMCID: PMC6528331.
  • Nassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, Sellitto A, Rizzo F, Malanga D, Mirante T, Morelli E, Nees M, Åkerfelt M, Kangaspeska S, Nyman TA, Milanesi L, Giurato G, Weisz A. Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells. Sci Adv. 2019 Feb 6;5(2):eaav5590. doi: 10.1126/sciadv.aav5590. eCollection 2019 Feb. PubMed PMID: 30775443; PubMed Central PMCID: PMC6365116
  • Ricciardi L, Col JD, Casolari P, Memoli D, Conti V, Vatrella A, Vonakis BM, Papi A, Caramori G, Stellato C. Differential expression of RNA-binding proteins in bronchial epithelium of stable COPD patients. Int J Chron Obstruct Pulmon Dis. 2018 Oct 12;13:3173-3190. doi: 10.2147/COPD.S166284. eCollection 2018. PubMed PMID: 30349226; PubMed Central PMCID: PMC6190813.
  • Belvedere R, Saggese P, Pessolano E, Memoli D, Bizzarro V, Rizzo F, Parente L,Weisz A, Petrella A. miR-196a Is Able to Restore the Aggressive Phenotype of Annexin A1 Knock-Out in Pancreatic Cancer Cells by CRISPR/Cas9 Genome Editing. Int J Mol Sci. 2018 Jul 6;19(7). pii: E1967. doi: 10.3390/ijms19071967. PubMed PMID: 29986379; PubMed Central PMCID: PMC6073506.
  • Lacunza E, Montanaro MA, Salvati A, Memoli D, Rizzo F, Henning MF, Quiroga IY, Guillou H, Abba MC, Gonzalez-Baro MDR, Weisz A, Pellon-Maison M. Small non-coding RNA landscape is modified by GPAT2 silencing in MDA-MB-231 cells. Oncotarget. 2018 Jun 15;9(46):28141-28154. doi: 10.18632/oncotarget.25582. eCollection 2018 Jun 15. PubMed PMID: 29963267; PubMed Central PMCID: PMC6021339.
  • Mauro L, Naimo GD, Gelsomino L, Malivindi R, Bruno L, Pellegrino M, Tarallo R, Memoli D, Weisz A, Panno ML, Andò S. Uncoupling effects of estrogen receptor α on LKB1/AMPK interaction upon adiponectin exposure in breast cancer. FASEB J. 2018 Aug;32(8):4343-4355. doi: 10.1096/fj.201701315R. Epub 2018 Mar 7. PubMed PMID: 29513571.
  • Panero R, Rinaldi A, Memoli D, Nassa G, Ravo M, Rizzo F, Tarallo R, Milanesi L, Weisz A, Giurato G. iSmaRT: A toolkit for a comprehensive analysis of small RNA-Seq data. Bioinformatics. 2017 Mar 15;33(6):938-940. Doi: 10.1093/bioinfomatics/btw734. PubMed PMID: 28057684.
  • Pazienza V, Panebianco C, Rappa F, Memoli D, Borghesan M, Cannito S, Oji A, Mazza G, Tamburrino D, Fusai G, Barone R, Bolasco G, Villarroya F, Villarroya J, Hatsuzawa K, Cappello F, Tarallo R, Nakanishi T, Vinciguerra M. Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis. Epigenetics Chromatin. 2016 Oct 25;9:45. PubMed PMID: 27800025; PubMed Central PMCID: PMC5078890.
  • Caporali S, Alvino E, Lacal PM, Levati L, Giurato G, Memoli D, Caprini E,Antonini Cappellini GC, D'Atri S. Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor. Int J Oncol. 2016 Sep;49(3):1164-74. doi: 10.3892/ijo.2016.3594. PubMed PMID: 27572607.
  • Porta A, Petrone AM, Morello S, Granata I, Rizzo F, Memoli D, Weisz A, Maresca B. Design and expression of peptides with antimicrobial activity against Salmonella typhimurium. Cell Microbiol. 2016 Jul 12. doi: 10.1111/cmi.12645. [Epub ahead of print] PubMed PMID: 27404739.
  • Dago DN, Scafoglio C, Rinaldi A, Memoli D, Giurato G, Nassa G, Ravo M, Rizzo F, Tarallo R, Weisz A. Estrogen receptor beta impacts hormone-induced alternative mRNA splicing in breast cancer cells. BMC Genomics. 2015 May 9;16:367. doi: 10.1186/s12864-015-1541-1. PubMed PMID: 25956916; PubMed Central PMCID: PMC4424892.

Riassunti pubblicati in atti di convegni nazionali/internazionali:

  • Memoli D, Tarallo R, Giurato G and Weisz A. Analysis of NGS data for the identification of mutations involved in the pathogenesis of rare tumors. NETTAB / BBCC 2019 Meeting, 11-13 November 2019, Salerno, Italy.
  • Gigantino V, Salvati A, Nassa G, Giurato G, Rizzo F, Mirici Cappa V, Memoli D, Weisz A, Tarallo R. Functional effect of DOT1L pharmacological inhibi-tion in ERα-positive Ovarian Cancer cells. 61th Annual Meeting of the Can-cer Society. 6-8 November 2019, Naples, Italy.
  • Polcaro G, Giurato G, Bruno R, Muccillo L, Memoli D, Rizzo F, Bonapace Ian Marc, Mollevi GD, Colantuoni V, Weisz A and Sabatino L. Conditioned me-dia from cancer-associated fibroblasts induce epigenetic modifications responsible for Epithelial Mesenchymal Transition in colorectal cancer cells. 61th Annual Meeting of the Cancer Society. 6-8 November 2019, Naples, Italy.
  • Gigantino V, Salvati A, Alexandrova E, Giurato G, Memoli D, Rizzo F, Sellitto A, Malanga D, Nyman TA, Tarallo R, Weisz A and Nassa G. Pharmacological inhibition of the histone methyltransferase DOT1L as a new epigenetic approach to therapy for endocrine resistant breast cancer. 1st INTERNA-TIONAL AND 32nd Annual Conference of Italian Association of Cell Cultu-res (AICC). 1-2 October 2019, Catanzaro, Italy.
  • Trino S, De Luca L, Caivano A, Laurenzana I, Zoppoli P, La Rocca F, Calice G, Simeon V, Memoli D, Weisz A, Cilloni D, Falco G, Carella AM, Del Vecchio L, Musto P. Genome wide methylation in hematopoietic stem cell after allogeneic bone marrow transplantation. SIES. 18-20 June 2018, Rimini, Ita-ly.
  • Polcaro G, Bruno R, Rizzo F, Memoli D, Weisz A, Mancini M, Mandruzzato M, Bonapace IM, Mollevi GD, Sabatino L, Colantuoni V. Conditioned media from cancer-associated fibroblasts induce epigenetic modifications re-sponsible for Epithelial Mesenchymal Transition in colorectal cancer cells. SIBBM. 20-22 June 2018, Roma, Italy.
  • Muccillo L, Polcaro G, De Marino MG, Macchi F, Magnani E, Mancini M, Riz-zo F, Memoli D, Weisz A, Colantuoni V, Sabatino L, Bonapace IM. Lower UHRF1 overexpression is linked to higher DNA methylation of eighty-three selectedgenes and associated with worse prognosis in colorectal cancer. SIBBM. 20-22 June 2018, Roma, Italy.
  • Trino S, De Luca L, Caivano A, Laurenzana I, Zoppoli P, La Rocca F, Calice G, Simeon V, Memoli D, Weisz A, Cilloni D, Falco G, Carella AM, Del Vecchio L Musto P. Genome wide methylation in hematopietic stem cell after al-logeneic bone marrow transplatation. 23nd Congress of the European He-matology Association. 14-17 June 2018, Stockholm, Sweden.
  • Memoli D, Salvati A, Rizzo F, Weisz A. Role of GPAT2 silencing in small RNA landscape in human MDA-MB-231 breast cancer cells. National Ph.D Meeting. 22-24 March 2018, Salerno, Italy.
  • Rinaldi A, Rizzo F, Sellitto A, Memoli D, Trapani D, Sahnane N, Furlan D, Giurato G, Weisz A. Involvement of PIWI-interacting RNAs in different molecular and clinicopathological subclasses of colon cancer. 14th Annual Meeting of the Bioinformatics Italian Society, Cagliari(IT), 5-7/07/2017.
  • Memoli D, Rinaldi A, Giurato G, Salvati A, Rizzo F, Weisz A. Analysis of miRNA and piRNA biogenesis in breast cancer cells. 14th Annual Meeting of the Bioinformatics Italian Society, Cagliari(IT), 5-7/07/2017.
  • Memoli D, Rinaldi A, Panero R, Nassa G, Rizzo F, Ravo M, Tarallo R, Weisz A, Giurato G. Comprehensive analysis of small RNA-Seq data with the iSmaRT toolkit. BBCC2016, 16 Dicembre 2016, Avellino, Italy.
  • Memoli D, Giurato G, Nassa G, Salvati A, Rizzo F and Weisz A. Integration of RRBS, smallRNA-Seq and RNA-Seq data for biological interpretation. Bioinformatics Italian Society, Tredicesimo congresso annuale BITS, 15-17 Giugno 2016, Salerno, Italy. Supported the organization and poster.
  • Ravo M, Montico B, Tarallo R, Giurato G, Memoli D, Martorelli D, Weisz A, Dolcetti R, Dal Col J. Coding- and non coding-RNA profiling of active dendritic cells following stimulation with highly immunogenic tumor cell lysates. 14th CIMT Annual Meeting, 10-12 Maggio 2016, Meinz, Germany.
  • Memoli D. Workshop Epigen “Data on the Beach”. Epigen, 5-6 Maggio 2016, Rimini, Italy. Speaker.
  • Memoli D, Giurato G, Nassa G, Ravo M, Ricciardi L, Rizzo F, Saggese P, Tarallo R, Weisz A, Identification and expression profiling of Piwi-Interacting RNAs (piRNAs) in cancer cells line, Bioinformatics Italian Society, Dodicesimo congresso annuale BITS, 3-5 Giugno 2015, Milano, Italy.
  • Giurato G, Rinaldi A, Hashim A, Nassa G, Ravo M, Rizzo F, Tarallo R, Cordella A, Marchese G, Memoli D, Weisz A, iMIR: an innovative and complete pipeline for smallRNA-Seq data analysis, EMBnet Journal, 21.A, COST Conference “Next Generation Sequencing: a look into the future” 16-17 Marzo 2015, Bratislava, Slovacchia.
  • Rinaldi A, Giurato G, Hashim A, Rizzo F, Marchese G, Ravo M, Santamaria G, Memoli D, Tarallo R, Nassa G, Guacci A, Rocco T, Weisz A. A Innovative and Complete Workflow for smallRNA-Seq Data Analysis. Proceedings of the 64° Congresso Nazionale AIPaCMeM - 32° Congresso Nazionale SIPMeT, 17-20 Settembre 2014, Palermo, Italy.
  • Santamaria G, Rinaldi A, Dago DN, Giurato G, Ravo M, Tarallo R, Nassa G, Rizzo F, Hashim A, Memoli D, Ricciardi L, Cordella A, Weisz A. RNA-Seq Analysis Reveals Effects of Ligand-Activated Estrogen Receptor Beta (ERβ) on Alternative Splicing Patterns in Breast Cancer Cells. Proceedings of the 64° Congresso Nazionale AIPaCMeM - 32° Congresso Nazionale SIPMeT, 17-20 Settembre 2014, Palermo, Italy.
  • Hashim A, Rizzo F, Marchese G, Memoli D, Weisz A. Analysis of Piwi-Interacting RNA (piRNA) Expression Pattern in Breast Cancer Cell Lines and Tumor Tissues. Proceedings of the FarMed - "Giornate della Facoltà di Farmacia e Medicina", Università degli studi di Salerno, 22-23 Maggio 2014. (Translational Medicine @ UniSa - Special Issue (1): 41).
  • Rinaldi A, Rizzo F, Hashim A, Marchese G, Cordella A, Sellitto A, Memoli D, Rocco T, Sulas P, Perra A, Ledda-Columbano GM, Columbano A, Weisz A. Piwi-Interacting RNAs (piRNAs) Expression Profiling During Rat Liver Regeneration. Proceedings of the FarMed - "Giornate della Facoltà di Farmacia e Medicina", Università degli studi di Salerno, 22-23 Maggio 2014. (Translational Medicine @ UniSa - Special Issue (1): 53).
  • Giurato G, Rinaldi A, Hashim A, De Filippo MR, Memoli D, Weisz A. iMir: A reliable and accurate pipeline for analysis of small non-coding RNA sequencing datasets. Proceedings of the 55th Annual Meeting of the Italian Cancer Society "Understanding onc-OMICS for patient-tailored cancer therapy", 23-26 September. 2013. Catanzaro, Italy. (pg. 90).