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LabMedMolGe - Attività di ricerca

Attività di ricerca

Il Laboratorio di Medicina Molecolare e Genomica esercita le sue attività di ricerca in diversi settori, ecco la lista delle principali pubblicazioni:     

  • Sulas P, Di Tommaso L, Novello C, Rizzo, F, Rinaldi, A, Weisz A, Columbano A, Roncalli M. A large set of miRNAs is dysregulated since the earliest steps of human hepatocellular carcinoma development. The American Journal of Pathology. Vol. In press. Pag.1-27 ISSN:0002-9440.
  • Giurato G, Nassa G, Salvati A, Alexandrova E, Rizzo F, Nyman TA, Weisz A, Tarallo R. Quantitative mapping of RNA-mediated nuclear Estrogen Receptor β interactome in human breast cancer cells. Scientific Data. Vol. In Press. Pag.1-10 ISSN:2052-4463.
  • Nassa G, Giurato G, Cimmino G, Rizzo F, Ravo M, Salvati A, Nyman TA. Zhu Y, Vesterlund M, Lehtiö J, Golino P, Weisz A, Tarallo R. Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications. Scientific Reports. Vol. In press. Pag.1-12.ISSN:2045-2322.
  • Tarallo R, Giurato G, Bruno G, Ravo M, Rizzo F, Salvati A, Ricciardi L, Marchese G, Cordella A, Rocco T, Gigantino V, Pierri B, Cimmino G, Milanesi L, Ambrosino C, Nyman TA, Nassa G, Weisz A. The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Genome Biol.2017 Oct 6;18(1):189. doi: 10.1186/s13059-017-1321-0. PubMed PMID: 29017520.
  • Montico B, Lapenta C, Ravo M, Martorelli D, Muraro E, Zeng B, Comaro E, Spada M, Donati S, Santini SM, Tarallo R, Giurato G., Rizzo F, Weisz A, Belardelli F, Dolcetti R, Dal Col J. Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy. Oncoimmunology. 2017 Aug 23.
  • Pistore C, Giannoni E, Colangelo T, Rizzo F, Magnani E, Muccillo L, Giurato G, Mancini M, Rizzo S, Riccardi M, Sahnane N, Del Vescovo V, Kishore K, Mandruzzato M, Macchi F, Pelizzola M, Denti MA, Furlan D, Weisz A, Colantuoni V, Chiarugi P, Bonapace IM. DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.159. [Epub ahead of print] PubMed PMID: 28581528.
  • Panero R, Rinaldi A, Memoli D, Nassa G, Ravo M, Rizzo F, Tarallo R, Milanesi L, Weisz A, Giurato G. iSmaRT: a toolkit for a comprehensive analysis of small RNA-Seq data. Bioinformatics. 2017 Mar 15;33(6):938-940. doi:10.1093/bioinformatics/btw734. PubMed PMID: 28057684.
  • Porta A, Petrone AM, Morello S, Granata I,Rizzo F, Memoli D, Weisz A, Maresca B. Design and expression of peptides with antimicrobial activity against Salmonella typhimurium. Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12645.
  • Porreca I, D'Angelo F, De Franceschi L, Mattè A, Ceccarelli M, Iolascon A, Zamò A, Russo F, Ravo M, Tarallo R, Scarfò M, Weisz A, De Felice M, Mallardo M, Ambrosino C. Pesticide toxicogenomics across scales: in vitro transcriptome predicts mechanisms and outcomes of exposure in vivo. Sci Rep. 2016 Dec 1;6:38131. doi: 10.1038/srep38131. PubMed PMID: 27905518; PubMed Central PMCID: PMC5131489.
  • Cuomo D, Porreca I, Cobellis G, Tarallo R, Nassa G, Falco G, Nardone A, Rizzo F, Mallardo M, Ambrosino C. Carcinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands. Mol Cell Endocrinol. 2017 Dec 5;457:20-34. doi: 10.1016/j.mce.2017.01.027. Epub 2017 Jan 19. PubMed PMID:28111205.
  • Lo Piccolo L, Attardi A, Bonaccorso R, Li Greci L, Giurato G, Ingrassia AM, Onorati MC. ISWI ATP-dependent remodeling of nucleoplasmic ω-speckles in the brain of Drosophila melanogaster. J Genet Genomics. 2017 Feb 20;44(2):85-94. doi: 10.1016/j.jgg.2016.12.002. Epub 2016 Dec 22. PubMed PMID: 28209301.
  • D'Arcangelo D, Facchiano F, Nassa G, Stancato A, Antonini A, Rossi S, Senatore C, Cordella M, Tabolacci C, Salvati A, Tarallo R, Weisz A, Facchiano AM, Facchiano A. PDGFR-alpha inhibits melanoma growth via CXCL10/IP-10: a multi-omics approach. Oncotarget. 2016 Nov 22;7(47):77257-77275. doi: 10.18632/oncotarget.12629. PubMed PMID: 27764787; PubMed Central PMCID: PMC5363585.
  • Fiume G, Scialdone A, Rizzo F, De Filippo MR, Laudanna C, Albano F, Golino G, Vecchio E, Pontoriero M, Mimmi S, Ceglia S, Pisano A, Iaccino E, Palmieri C, Paduano S, Viglietto G, Weisz A, Scala G, Quinto I. IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells. Int J Mol Sci. 2016 Nov 7;17(11). pii: E1848
  • Pazienza V, Panebianco C, Rappa F, Memoli D, Borghesan M, Cannito S, Oji A, Mazza G, Tamburrino D, Fusai G, Barone R, Bolasco G, Villarroya F, Villarroya J, Hatsuzawa K, Cappello F, Tarallo R, Nakanishi T, Vinciguerra M. Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis. Epigenetics Chromatin. 2016 Oct 25;9:45. eCollection 2016. PubMed PMID: 27800025; PubMed Central PMCID: PMC5078890.
  • Santangelo L, Giurato G*, Cicchini C, Montaldo C, Mancone C, Tarallo R, Battistelli C, Alonzi T, Weisz A, Tripodi M. The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Cell Rep. 2016 Oct 11;17(3):799-808. doi: 10.1016/j.celrep.2016.09.031. PubMed PMID: 27732855.*Co-first author.
  • Caporali S, Alvino E, Lacal PM, Levati L, Giurato G, Memoli D, Caprini E, Antonini Cappellini GC, D'Atri S. Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor. Int J Oncol. 2016 Sep;49(3):1164-74. doi: 10.3892/ijo.2016.3594. Epub 2016 Jun 30. PubMed PMID: 27572607.
  • De Palma R, Cirillo P, Ciccarelli G, Barra G, Conte S, Pellegrino G, Pasquale G, Nassa G, Pacifico F, Leonardi A, Insabato L, Calì G, Golino P, Cimmino G. Expression of functional tissue factor in activated T-lymphocytes in vitro and in vivo: A possible contribution of immunity to thrombosis? Int J Cardiol. 2016 Sep 1;218:188-195. doi: 10.1016/j.ijcard.2016.04.177. Epub 2016 May 3. PubMed PMID: 27236113.
  • Rizzo F, Rinaldi A, Marchese G, Coviello E, Sellitto A, Cordella A, Giurato G, Nassa G, Ravo M, Tarallo R, Milanesi L, Destro A, Torzilli G, Roncalli M, Di Tommaso L, Weisz A. Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma. Oncotarget. 2016 Aug 23;7(34):54650-54661. doi: 10.18632/oncotarget.10567. PubMed PMID: 27429044; PubMed Central PMCID: PMC5342370.
  • Marchese G, Rizzo F, Guacci A, Weisz A, Coppola G. Kleefstra-variant syndrome with heterozygous mutations in EHMT1 and KCNQ2 genes: a case report. Neurol Sci. 2016 May;37(5):829-31. doi: 10.1007/s10072-016-2482-4. 
  • Rizzo F, Coffman JA, Arnone MI. An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo. Dev Biol. 2016 Aug 1;416(1):173-186. doi: 10.1016/j.ydbio.2016.05.026. Epub 2016 May 24.
  • Alexandrova E, Nassa G, Corleone G, Buzdin A, Aliper AM, Terekhanova N, Shepelin D, Zhavoronkov A, Tamm M, Milanesi L, Miglino N, Weisz A, Borger P. Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells. Oncotarget. 2016 May 3;7(18):25150-61. doi: 10.18632/oncotarget.7209. PubMed PMID: 26863634; PubMed Central PMCID: PMC5039037.
  • Catalano S, Campana A, Giordano C, Győrffy B, Tarallo R, Rinaldi A, Bruno G, Ferraro A, Romeo F, Lanzino M, Naro F, Bonofiglio D, Andò S, Barone I. Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy. Clin Cancer Res. 2016 May 1;22(9):2271-82. doi: 10.1158/1078-0432.CCR-15-1900. Epub 2015 Dec 14. PubMed PMID: 26667489.
  • Rizzo F, Ambrosino P, Guacci A, Chetta M, Marchese G, Rocco T, Soldovieri MV, Manocchio L, Mosca I, Casara G, Vecchi M, Taglialatela M, Coppola G, Weisz A. Characterization of two de novoKCNT1 mutations in children with malignant migrating partial seizures in infancy. Mol Cell Neurosci. 2016 Apr;72:54-63. doi:10.1016/j.mcn.2016.01.004. 
  • Alexandrova E, Miglino N, Hashim A, Nassa G, Stellato C, Tamm M, Baty F, Brutsche M, Weisz A, Borger P. Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic patients. J Allergy Clin Immunol. 2016 Jan;137(1):58-67. doi: 10.1016/j.jaci.2015.05.031. Epub 2015 Jul 3. PubMed PMID: 26148798
  • Guacci A, Chetta M, Rizzo F, Marchese G, De Filippo MR, Giurato G, Nassa G, Ravo M, Tarallo R, Rocco T, Operto FF, Weisz A, Coppola G. Phenytoin neurotoxicity in a child carrying new STXBP1 and CYP2C9 gene mutations. Seizure. 2016 Jan;34:26-8. doi: 10.1016/j.seizure.2015.11.004. Epub 2015 Nov 21. PubMed PMID: 26658169.
  • De Rosa MC, Caputo M, Zirpoli H, Rescigno T, Tarallo R, Giurato G, Weisz A, Torino G, Tecce MF. Identification of Genes Selectively Regulated in Human Hepatoma Cells by Treatment With Dyslipidemic Sera and PUFAs. J Cell Physiol. 2015 Sep;230(9):2059-66. doi: 10.1002/jcp.24932. PubMed PMID: 25639214.
  • Chetta M, Guacci A, Rizzo F,  Operto FF, Weisz A, and Coppola G.  Infantile spasms in early-onset Niemann-Pick disease with a novel compound heterozygous mutations in SMPD1 gene. New Horizons in Translational Medicine. 2015 Sep; 2(6-7):155-158 doi: 10.1016/j.nhtm.2015.11.001.
  • Stellato C, Porreca I, Cuomo D, Tarallo R, Nassa G, Ambrosino C. The "busy life" of unliganded estrogen receptors. Proteomics. 2016 Jan;16(2):288-300. doi: 10.1002/pmic.201500261. Epub 2015 Dec 17. Review. PubMed PMID: 26508451..
  • Pibiri M, Sulas P, Leoni VP, Perra A, Kowalik MA, Cordella A, Saggese P, Nassa G, Ravo M. Global gene expression profile of normal and regenerating liver in young and old mice. Age (Dordr). 2015 Jun;37(3):9796. doi: 10.1007/s11357-015-9796-7. Epub 2015 Jun 3. PubMed PMID: 26036689; PubMed Central PMCID: PMC4451458.
  • Cimmino G, Tarallo R, Nassa G, De Filippo MR, Giurato G, Ravo M, Rizzo F, Conte S, Pellegrino G, Cirillo P, Calabro P, Öhman T, Nyman TA, Weisz A, Golino P. Activating stimuli induce platelet microRNA modulation and proteome reorganisation. Thromb Haemost. 2015 Jul;114(1):96-108. doi: 10.1160/TH14-09-0726. Epub 2015 Apr 23. PubMed PMID: 25903651.
  • Dago DN, Scafoglio C, Rinaldi A, Memoli D, Giurato G, Nassa G, Ravo M, Rizzo F, Tarallo R, Weisz A. Estrogen receptor beta impacts hormone-induced alternative mRNA splicing in breast cancer cells. BMC Genomics. 2015 May 9;16:367. doi: 10.1186/s12864-015-1541-1. PubMed PMID: 25956916; PubMed Central PMCID: PMC4424892.
  • Stellato C, Nassa G, Tarallo R, Giurato G, Ravo M, Rizzo F, Marchese G, Alexandrova E, Cordella A, Baumann M, Nyman TA, Weisz A, Ambrosino C. Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells. Proteomics. 2015 Jun;15(11):1801-7. doi: 10.1002/pmic.201400404. Epub 2015 Mar 18. PubMed PMID: 25604459.
  • Ravo M, Cordella A, Rinaldi A, Bruno G, Alexandrova E, Saggese P, Nassa G, Giurato G, Tarallo R, Marchese G, Rizzo F, Stellato C, Biancardi R, Troisi J, Di Spiezio Sardo A, Zullo F, Weisz A, Guida M. Small non-coding RNA deregulation in endometrial carcinogenesis. Oncotarget. 2015 Mar 10;6(7):4677-91. PubMed PMID: 25686835; PubMed Central PMCID: PMC4467107.
  • Caputo M, Zirpoli H, De Rosa MC, Rescigno T, Chiadini F, Scaglione A, Stellato C, Giurato G, Weisz A, Tecce MF, Bisceglia B. Effect of low frequency (LF) electric fields on gene expression of a bone human cell line. Electromagn Biol Med. 2014 Dec;33(4):289-95. doi: 10.3109/15368378.2013.822387. Epub 2013 Aug 26. PubMed PMID: 23977831.
  • Misaggi R, Di Sanzo M, Cosentino C, Bond HM, Scumaci D, Romeo F, Stellato C, Giurato G, Weisz A, Quaresima B, Barni T, Amato F, Viglietto G, Morrone G, Cuda G, Faniello MC, Costanzo F. Identification of H ferritin-dependent and independent genes in K562 differentiating cells by targeted gene silencing and expression profiling. Gene. 2014 Feb 10;535(2):327-35. doi: 10.1016/j.gene.2013.10.067. Epub 2013 Nov 14. PubMed PMID: 24239552.
  • Hashim A, Rizzo F, Marchese G, Ravo M, Tarallo R, Nassa , Giurato G, Santamaria G, Cordella A, Cantarella C, Weisz A. RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer. Oncotarget. 2014 Oct 30;5(20):9901-10. PubMed PMID: 25313140; PubMed Central PMCID: PMC4259446.
  • Rizzo F, Hashim A, Marchese G, Ravo M, Tarallo R, Nassa G, Giurato G, Rinaldi A, Cordella A, Persico M, Sulas P, Perra A, Ledda-Columbano GM, Columbano A, Weisz A. Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration. Hepatology. 2014 Sep;60(3):798-806. doi: 10.1002/hep.27267. Epub 2014 Jul 1. PubMed PMID: 24930433.
  • Nassa G, Tarallo R, Giurato G, De Filippo MR, Ravo M, Rizzo F, Stellato C,Ambrosino C, Baumann M, Lietzèn N, Nyman TA, Weisz A. Post-transcriptionalregulation of human breast cancer cell proteome by unliganded estrogen receptor β via microRNAs. Mol Cell Proteomics. 2014 Apr;13(4):1076-90. doi:10.1074/mcp.M113.030403. Epub 2014 Feb 13. PubMed PMID: 24525454; PubMed Central PMCID: PMC3977185.
  • Strazzullo M, Gasparrini B, Neglia G, Balestrieri ML, Francioso R, Rossetti C, Nassa G, De Filippo MR, Weisz A, Di Francesco S, Vecchio D, D'Esposito M, D'Occhio MJ, Zicarelli L, Campanile G. Global transcriptome profiles of Italian Mediterranean buffalo embryos with normal and retarded growth. PLoS One. 2014 Feb 28;9(2):e90027. doi: 10.1371/journal.pone.0090027. eCollection 2014. PubMed PMID: 24587197; PubMed Central PMCID: PMC3938533.
  • Casale FP, Giurato G, Nassa G, Armond JW, Oates CJ, Corá D, Gamba A, Mukherjee S, Weisz A, Nicodemi M. Single-cell states in the estrogen response of breast cancer cell lines. PLoS One. 2014 Feb 25;9(2):e88485. doi: 10.1371/journal.pone.0088485. eCollection 2014. PubMed PMID: 24586334; PubMed Central PMCID: PMC3934861
  • Giurato G, De Filippo M.R, Rinaldi A, Hashim A, Nassa G, Ravo M, Rizzo F, Tarallo R, Weisz A. iMir: An Integrated pipeline for high-throughput analysis of small non-coding data obtained by miRNA-Seq. BMC Bioinformatics. 2013 Dec 13;14:362. doi: 10.1186/1471-2105-14-362. PubMed PMID: 24330401; PubMed Central PMCID: PMC3878829.
  • De Filippo M.R, Rizzo F, Marchese G, Giurato G, Nassa G, Ravo M, Tarallo R, Pironti E, Vecchi M, Crichiutti G, Capizzi G, Verrotti A, Weisz A, Coppola G. Lack of pathogenic mutations in six patients with MMPSI. Epilepsy Res. 2014 Feb;108(2):340-4. doi:10.1016/j.eplepsyres.2013.11.007. Epub 2013 Nov 16. PubMed PMID: 24315024.
  • Ambrosino C, Tarallo R, Nassa G, Cirillo F, Weisz. A new insights on estrogen receptor actions in hormone-responsive breast cancer cells by interaction proteomics. Cell and Molecular biology of breast cancer: Heide Shutter editor, Humana press. Chapter 8, DOI 10.1007/978-1-62703-634-4_8, 2013
  • Cirillo F, Nassa G, Tarallo R, Stellato C, De Filippo MR, Ambrosino C, Baumann M, Nyman TA, Weisz A. Molecular mechanisms of selective estrogen receptor modulator activity in human breast cancer cells: identification of novel nuclear cofactors of antiestrogen-ERα complexes by interaction proteomics. J Proteome Res. 2013 Jan 4;12(1):421-31. doi: 10.1021/pr300753u. Epub 2012 Nov 30. PubMed PMID: 23170835.
  • Ferraro L, Ravo M, Nassa G, Tarallo R, De Filippo MR, Giurato G, Cirillo F, Stellato C, Silvestro S, Cantarella C, Rizzo F, Cimino D, Friard O, Biglia N, De Bortoli M, Cicatiello L, Nola E, Weisz A. Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells. Horm Cancer. 2012 Jun;3(3):65-78. doi: 10.1007/s12672-012-0102-1. PubMed PMID: 22274890
  • Paris O, Ferraro L, Grober OM, Ravo M, De Filippo MR, Giurato G, Nassa G, Tarallo R, Cantarella C, Rizzo F, Di Benedetto A, Mottolese M, Benes V, Ambrosino C, Nola E, Weisz A. Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer. Oncogene. 2012 Sep 20;31(38):4196-206. doi: 10.1038/onc.2011.583. Epub 2012 Jan 9. PubMed PMID: 22231442
  • Grober OM, Mutarelli M, Giurato G, Ravo M, Cicatiello L, De Filippo MR, Ferraro L, Nassa G, Papa MF, Paris O, Tarallo R, Luo S, Schroth GP, Benes V, Weisz A. Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 2011 Jan 14;12:36. doi: 10.1186/1471-2164-12-36. PubMed PMID: 21235772; PubMed Central PMCID: PMC3025958.