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LabMedMolGe - Team

Maria Ravo

Maria Ravo

AIRC

e-mail: mravo@unisa.it

 

Laurea in Biotecnologie per la Salute e per l'Ambiente cum laude, Seconda Università degli Studi di Napoli (2006)

 

Dottorato in Tossicologia, Oncologia e Patologia molecolare - Università degli Studi di Cagliari (2007-2009)

 

Socio Fondatore della start-up innovativa Genomix4Life S.r.l., spin-off dell'Università degli Studi di Salerno (www.genomix4life.com)

 

Competenze ed attività di ricerca: Analisi globale del ruolo dei piccoli RNA non codificanti nel carcinoma mammario. Genomica, bioinformatica, biologia molecolare e cellulare. Applicazione di tecnologie di nuova generazione per il Sequenziamento Massivo Parallelo di interi genomi, esomi, trascrittomi e RNA non codificanti.


Borsista nell'ambito del progetto finanziato dalla Fondazione con il Sud: 'Formazione di capitale umano di eccellenza nel settore delle biotecnologie applicate alla medicina per l'inserimento nel mondo del lavoro di giovani talenti delle regioni del sud Italia' (2010 - 2011)

 

Borsista A.I.R.C. (borsa di studio triennale "Vladimir Ashkenazy" dell'Associazione Italiana per la Ricerca sul Cancro; 2012-2014)  

 

Titolare di Assegno di Ricerca nell'ambito del progetto: "La Genomica e la Bioinformatica nello studio delle patologie complesse e trasferimento tecnologico" presso l'Università degli Studi di Salerno (2015 - 2017).

Responsabile dell'Unità Operativa dell'Università degli Studi di Salerno, nell'ambito del Progetto di Ricerca dal titolo: "Role of microRNA in immunogenic tumor cell death" Giovani Ricercatori - Ricerca Finalizzata 2011-2012 del Ministero della Salute (da Nov. 2013)

 

Pubblicazioni:

  • Alexandrova E, Lamberti J, Saggese P, Pecoraro G, Memoli D, Mirici Cappa V, Ravo M, Iorio R, Tarallo R, Rizzo F, Collina F, Cantile M, Bonito MD, Botti G, Nassa G, Weisz A, Giurato G. Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer. Cells. 2020 Apr 3;9(4):E874. doi: 10.3390/cells9040874. PMID: 32260128.
  • Alexandrova E, Giurato G, Saggese P, Pecoraro G, Lamberti J, Ravo M, Rizzo F, Rocco D, Tarallo R, Nyman TA, Collina F, Cantile M, Di Bonito M, Botti G, Nassa G, Weisz A. Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer. Mol Cell Proteomics. 2020 Feb;19(2):245-260. doi: 10.1074/mcp.RA119.001817. Epub 2019 Dec 2. PMID: 31792072; PMCID: PMC7000115.
  • Ravo M, Cordella A, Saggese P, Rinaldi A, Castaldi MA, Nassa G, Giurato G,Zullo F, Weisz A, Tarallo R, Rizzo F, Guida M. Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers. Oncol Rep. 2019 Feb;41(2):1209-1217. doi: 10.3892/or.2018.6880. Epub 2018 Nov 21. PubMed PMID: 30483802.
  • Nassa G, Giurato G, Cimmino G, Rizzo F, Ravo M, Salvati A, Nyman TA. Zhu Y, Vesterlund M, Lehtiö J, Golino P, Weisz A, Tarallo R. Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications. Sci Rep. 2018 Jan 11;8(1):498. doi: 10.1038/s41598-017-18985-5. PubMed PMID: 29323256; PubMed Central PMCID: PMC5765118.
  • Tarallo R, Giurato G, Bruno G, Ravo M, Rizzo F, Salvati A, Ricciardi L, Marchese G, Cordella A, Rocco T, Gigantino V, Pierri B, Cimmino G, Milanesi L, Ambrosino C, Nyman TA, Nassa G, Weisz A. The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Genome Biol.2017 Oct 6;18(1):189. doi: 10.1186/s13059-017-1321-0. PubMed PMID: 29017520.
  • Montico B, Lapenta C, Ravo M, Martorelli D, Muraro E, Comaro E, Spada M, Donati S, Santini S, Tarallo R, Giurato G, Rizzo F, Weisz A, Belardelli F, Dolcetti R, Dal Col J. Exploiting immunogenic cell death features for improved dendritic cell-based therapeutic vaccine against mantle cell lymphoma. OncoImmunology, 2017. In Press
  • De Marco C, Laudanna C, Rinaldo N, Oliveira DM, Ravo M, Weisz A, Ceccarelli M, Caira E, Rizzuto A, Zoppoli P, Malanga D, Viglietto G. Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. PLoS One. 2017 Jun 29;12(6):e0178865.
  • Guerriero I, D'Angelo D, Pallante P, Santos M, Scrima M, Malanga D, De Marco C, Ravo M, Weisz A, Laudanna C, Ceccarelli M, Falco G, Rizzuto A, Viglietto G. Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells. Oncotarget. 2017 Mar 21;8(12):19172-19191.
  • Panero R, Rinaldi A, Memoli D, Nassa G, Ravo M, Rizzo F, Tarallo R, Milanesi L, Weisz A, Giurato G. iSmaRT: a toolkit for a comprehensive analysis of small RNA-Seq data. Bioinformatics. 2017 Mar 15;33(6):938-940.
  • Porreca I, D'Angelo F, De Franceschi L, Mattè A, Ceccarelli M, Iolascon A, Zamò A, Russo F, Ravo M, Tarallo R, Scarfò M, Weisz A, De Felice M, Mallardo M, Ambrosino C. Pesticide toxicogenomics across scales: in vitro transcriptome predicts mechanisms and outcomes of exposure in vivo. Sci Rep. 2016 Dec 1;6:38131.
  • Rizzo F, Rinaldi A, Marchese G, Coviello E, Sellitto A, Cordella A, Giurato G, Nassa G, Ravo M, Tarallo R, Milanesi L, Destro A, Torzilli G, Roncalli M, Di Tommaso L, Weisz A. Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma. Oncotarget. 2016 Aug 23;7(34):54650-54661.
  • Guacci A, Chetta M, Rizzo F, Marchese G, De Filippo MR, Giurato G, Nassa G, Ravo M, Tarallo R, Rocco T, Operto FF, Weisz A, Coppola G. Phenytoin neurotoxicity in a child carrying new STXBP1 and CYP2C9 gene mutations. Seizure. 2016 Jan;34:26-8.
  • Malanga D, De Marco C, Guerriero I, Colelli F, Rinaldo N, Scrima M, Mirante T, De Vitis C, Zoppoli P, Ceccarelli M, Riccardi M, Ravo M, Weisz A, Federico A, Franco R, Rocco G, Mancini R, Rizzuto A, Gulletta E, Ciliberto G, Viglietto G. The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells. Oncotarget. 2015 Dec 15;6(40):42667-86.
  • Cimmino G, Tarallo R, Nassa G, De Filippo MR, Giurato G, Ravo M, Rizzo F, Conte S, Pellegrino G, Cirillo P, Calabro P, Öhman T, Nyman TA, Weisz A, Golino P. Activating stimuli induce platelet microRNA modulation and proteome reorganisation. Thromb Haemost. 2015 Jul;114(1):96-108.
  • Chetta M, Cordella A, Bruno G, Guida M, Weisz A, Ravo M. Relationship between Mutations in DNA Sequences Loci Coding Pre-miRNAs and Genes Related to Biogenesis of sncRNAs with miRNA Expression in Endometrial Carcinoma Tissues. Journal of Environmental Science and Engineering, 2015;B4:372-379
  • Pibiri M, Sulas P, Leoni VP, Perra A, Kowalik MA, Cordella A, Saggese P, Nassa G, Ravo M. Global gene expression profile of normal and regenerating liver in young and old mice. Age (Dordr). 2015 Jun;37(3):9796.
  • Stellato C, Nassa G, Tarallo R, Giurato G, Ravo M, Rizzo F, Marchese G, Alexandrova E, Cordella A, Baumann M, Nyman TA, Weisz A, Ambrosino C. Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells. Proteomics. 2015 Jun;15(11):1801-7.
  • Dago DN, Scafoglio C, Rinaldi A, Memoli D, Giurato G, Nassa G, Ravo M, Rizzo F, Tarallo R, Weisz A. Estrogen receptor beta impacts hormone-induced alternative mRNA splicing in breast cancer cells. BMC Genomics. 2015 May 9;16:367.
  • Ravo M, Cordella A, Rinaldi A, Bruno G, Alexandrova E, Saggese P, Nassa G, Giurato G, Tarallo R, Marchese G, Rizzo F, Stellato C, Biancardi R, Troisi J, Di Spiezio Sardo A, Zullo F, Weisz A, Guida M. Small non-coding RNA deregulation in endometrial carcinogenesis. Oncotarget. 2015 Mar 10;6(7):4677-91.
  • Hashim A, Rizzo F, Marchese G, Ravo M, Tarallo R, Nassa G, Giurato G, Santamaria G, Cordella A, Cantarella C, Weisz A. RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer. Oncotarget. 2014 Oct 30;5(20):9901-10. PubMed PMID: 25313140.
  • Rizzo F, Hashim A, Marchese G, Ravo M, Tarallo R, Nassa G, Giurato G, Rinaldi A, Cordella A, Persico M, Sulas P, Perra A, Ledda-Columbano GM, Columbano A, Weisz A. Timed regulation of P-element-induced wimpy testis interacting RNA expression during rat liver regeneration. Hepatology. 2014 Sep;60(3):798-806. doi: 10.1002/hep.27267. Epub 2014 Jul 1. PubMed PMID: 24930433. 
  • Nassa G, Tarallo R, Giurato G, De Filippo MR, Ravo M, Rizzo F, Stellato C,Ambrosino C, Baumann M, Lietzèn N, Nyman TA, Weisz A. Post-transcriptionalregulation of human breast cancer cell proteome by unliganded estrogen receptor β via microRNAs. Mol Cell Proteomics. 2014 Apr;13(4):1076-90. doi:10.1074/mcp.M113.030403. Epub 2014 Feb 13. PubMed PMID: 24525454; PubMed Central PMCID: PMC3977185.
  • Giurato G, De Filippo M.R, Rinaldi A, Hashim A, Nassa G, Ravo M, Rizzo F, Tarallo R, Weisz A. iMir: An Integrated pipeline for high-throughput analysis of small non-coding data obtained by miRNA-Seq. BMC Bioinformatics. 2013 Dec 13;14:362. doi: 10.1186/1471-2105-14-362. PubMed PMID: 24330401; PubMed Central PMCID: PMC3878829.
  • De Filippo M.R, Rizzo F, Marchese G, Giurato G, Nassa G, Ravo M, Tarallo R, Pironti E, Vecchi M, Crichiutti G, Capizzi G, Verrotti A, Weisz A, Coppola G. Lack of pathogenic mutations in six patients with MMPSI. Epilepsy Res. 2014 Feb;108(2):340-4. doi:10.1016/j.eplepsyres.2013.11.007. Epub 2013 Nov 16. PubMed PMID: 24315024.
  • Scrima M, De Marco C, Fabiani F, Franco R, Pirozzi G, Rocco G, Ravo M, Weisz A, Zoppoli P, Ceccarelli M, Botti G, Malanga D, Viglietto G. Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase. PLoS One. 2012;7(2):e30427. doi: 10.1371/journal.pone.0030427. Epub 2012 Feb 17. PubMed PMID: 22363436; PubMed Central PMCID: PMC3281846.
  • Ferraro L, Ravo M, Nassa G, Tarallo R, De Filippo MR, Giurato G, Cirillo F, Stellato C, Silvestro S, Cantarella C, Rizzo F, Cimino D, Friard O, Biglia N, De Bortoli M, Cicatiello L, Nola E, Weisz A. Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells. Horm Cancer. 2012 Jun;3(3):65-78. doi: 10.1007/s12672-012-0102-1. PubMed PMID: 22274890
  • Paris O, Ferraro L, Grober OM, Ravo M, De Filippo MR, Giurato G, Nassa G, Tarallo R, Cantarella C, Rizzo F, Di Benedetto A, Mottolese M, Benes V, Ambrosino C, Nola E, Weisz A. Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer. Oncogene. 2012 Sep 20;31(38):4196-206. doi: 10.1038/onc.2011.583. Epub 2012 Jan 9. PubMed PMID: 22231442
  • Benatti P, Dolfini D, Viganò A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011 Jul;39(13):5356-68. doi: 10.1093/nar/gkr128. Epub 2011 Mar 16. PubMed PMID: 21415014; PubMed Central PMCID: PMC3141247.
  • Leoni VP, Ledda-Columbano GM, Pibiri M, Saliba C, Perra A, Kowalik MA, Grober OM, Ravo M, Weisz A, Locker J, Ghiso E, Giordano S, Columbano A. Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3. J Hepatol. 2011 Nov;55(5):1069-78. doi: 10.1016/j.jhep.2011.02.016. Epub 2011 Feb 25. PubMed PMID: 21354444.
  • Grober OM, Mutarelli M, Giurato G, Ravo M, Cicatiello L, De Filippo MR, Ferraro L, Nassa G, Papa MF, Paris O, Tarallo R, Luo S, Schroth GP, Benes V, Weisz A. Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 2011 Jan 14;12:36. doi: 10.1186/1471-2164-12-36. PubMed PMID: 21235772; PubMed Central PMCID: PMC3025958.
  • Nassa G, Tarallo R, Ambrosino C, Bamundo A, Ferraro L, Paris O, Ravo M, Guzzi PH, Cannataro M, Baumann M, Nyman TA, Nola E, Weisz A. A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics. 2011 Jan;11(1):159-65. doi: 10.1002/pmic.201000344. Epub 2010 Dec 1. PubMed PMID: 21182203.
  • Nassa G, Tarallo R, Guzzi PH, Ferraro L, Cirillo F, Ravo M, Nola E, Baumann M, Nyman TA, Cannataro M, Ambrosino C, Weisz A. Comparative analysis of nuclear estrogen receptor alpha and beta interactomes in breast cancer cells. Mol Biosyst. 2011 Mar;7(3):667-76. doi: 10.1039/c0mb00145g. Epub 2010 Dec 20. PubMed PMID: 21173974.
  • Carlini F, Ridolfi B, Molinari A, Parisi C, Bozzuto G, Toccacieli L, Formisano G, De Orsi D, Paradisi S, Grober OM, Ravo M, Weisz A, Arcieri R, Vella S, Gaudi S. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221. doi: 10.1371/journal.pone.0014221. PubMed PMID: 21151977; PubMed Central PMCID: PMC2997057.
  • Borrelli S, Fanoni D, Dolfini D, Alotto D, Ravo M, Grober OM, Weisz A, Castagnoli C, Berti E, Vigano MA, Mantovani R. C/EBPδ gene targets in human keratinocytes. PLoS One. 2010 Nov 2;5(11):e13789. doi: 10.1371/journal.pone.0013789. PubMed PMID: 21072181; PubMed Central PMCID: PMC2970548.
  • Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A, Dotto GP, Melino G, Viganò MA, Mantovani R. The p63 target HBP1 is required for skin differentiation and stratification. Cell Death Differ. 2010 Dec;17(12):1896-907. doi: 10.1038/cdd.2010.59. Epub 2010 Jun 4. PubMed PMID: 20523354.
  • Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, Zinser C, Chiusano ML, Traini A, De Bortoli M, Weisz A. Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am J Pathol. 2010 May;176(5):2113-30. doi: 10.2353/ajpath.2010.090837. Epub 2010 Mar 26. PubMed PMID: 20348243; PubMed Central PMCID: PMC2861078.
  • Ambrosino C, Tarallo R, Bamundo A, Cuomo D, Franci G, Nassa G, Paris O, Ravo M, Giovane A, Zambrano N, Lepikhova T, Jänne OA, Baumann M, Nyman TA, Cicatiello L, Weisz A. Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Mol Cell Proteomics. 2010 Jun;9(6):1352-67. doi: 10.1074/mcp.M900519-MCP200. Epub 2010 Mar 22. PubMed PMID: 20308691; PubMed Central PMCID: PMC2877992.
  • Tosco A, Fontanella B, Danise R, Cicatiello L, Grober OM, Ravo M, Weisz A, Marzullo L. Molecular bases of copper and iron deficiency-associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome. Genes Nutr. 2010 Mar;5(1):1-8. doi: 10.1007/s12263-009-0153-2. Epub 2009 Oct 11. PubMed PMID: 19821111; PubMed Central PMCID: PMC2820196.
  • Mutarelli M, Cicatiello L, Ferraro L, Grober OM, Ravo M, Facchiano AM, Angelini C, Weisz A. Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells. BMC Bioinformatics. 2008 Mar 26;9 Suppl 2:S12. doi: 10.1186/1471-2105-9-S2-S12. PubMed PMID: 18387200; PubMed Central PMCID: PMC2323661.
  • Ravo M, Mutarelli M, Ferraro L, Grober OM, Paris O, Tarallo R, Vigilante A, Cimino D, De Bortoli M, Nola E, Cicatiello L, Weisz A. Quantitative expression profiling of highly degraded RNA from formalin-fixed, paraffin-embedded breast tumor biopsies by oligonucleotide microarrays. Lab Invest. 2008 Apr;88(4):430-40. doi: 10.1038/labinvest.2008.11. Epub 2008 Feb 25. PubMed PMID: 18305565.
  • Sismondi P, Biglia N, Ponzone R, Fuso L, Scafoglio C, Cicatiello L, Ravo M, Weisz A, Cimino D, Altobelli G, Friard O, De Bortoli M. Influence of estrogens and antiestrogens on the expression of selected hormone-responsive genes. Maturitas. 2007 May 20;57(1):50-5. Epub 2007 Mar 28. PubMed PMID: 17395409.