unisa ITA  unisa ENG


LabMedMolGe - Team

Elena Alexandrova

Elena Alexandrova

email: ealexandrova@unisa.it

 

Academic degree in Physical-Chemical Biology and Biotechnology at Moscow Institute of Physics and Technology (2005)

 

PhD in Molecular Biology at Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (2013)

 

Master in Innovations Research in Health Sciences, Genomics and Bioinformatics educational path, University of Salerno (2014)

 

Expertise and research activities: genomics, molecular and cellular biology. Application of massively parallel sequencing methods, for genome-wide analysis of mobile element expression. Genome, transcriptome, miRNA and other small non-coding RNA sequencing.

 

Publications:

  • Sellitto A, D’Agostino Y, Alexadrova E, Lamberti J, Pecoraro G, Memoli D, Rocco D, Coviello E, Giurato G, Nassa G, Tarallo R, Weisz A, Rizzo F. Insights into the  role of Estrogen Receptor Beta in Triple Negative Breast Cancer. Cancers. 2020 Jun 5;12(6):1477. doi: 10.3390/cancers12061477.
  • Alexandrova E, Pecoraro G, Sellitto A, Melone V, Ferravante C, Rocco T, Guacci A, Giurato G, Nassa G, Rizzo F, Weisz A, Tarallo R. An overview of candidate therapeutic target genes in ovarian cancer. Cancers. 2020 Jun 4;12(6):1470. doi: 10.3390/cancers12061470.
  • Alexandrova E, Lamberti J, Saggese P, Pecoraro G, Memoli D, Cappa VM, Ravo M, Iorio R, Tarallo R, Rizzo F, Collina F, Cantile M, Bonito MD, Botti G, Nassa G, Weisz A, Giurato G. Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer. Cells. 2020 Apr 3;9(4):E874. doi: 10.3390/cells9040874. PMID: 32260128.
  • Alexandrova E, Giurato G, Saggese P, Pecoraro G, Lamberti J, Ravo M, Rizzo F, Rocco D, Tarallo R, Nyman TA, Collina F, Cantile M, Di Bonito M, Botti G, Nassa G, Weisz A. Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer. Mol Cell Proteomics. 2020 Feb;19(2):245-260. doi: 10.1074/mcp.RA119.001817. Epub 2019 Dec 2. PMID: 31792072; PMCID: PMC7000115.
  • Sellitto A, Geles K, D'Agostino Y, Conte M, Alexandrova E, Rocco D, Nassa G, Giurato G, Tarallo R, Weisz A, Rizzo F. Molecular and Functional Characterization of the Somatic PIWIL1/piRNA Pathway in Colorectal Cancer Cells. Cells. 2019 Nov 5;8(11):1390. doi: 10.3390/cells8111390. PMID: 31694219; PMCID: PMC6912267.
  • Salvati A, Gigantino V, Nassa G, Giurato G, Alexandrova E, Rizzo F, Tarallo R, Weisz A. The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells. Cancers (Basel). 2019 Nov 4;11(11):1720. doi: 10.3390/cancers11111720. PMID: 31689915; PMCID: PMC6895927.
  • Nassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, Sellitto A, Rizzo F, Malanga D, Mirante T, Morelli E, Nees M, Åkerfelt M, Kangaspeska S, Nyman TA, Milanesi L, Giurato G, Weisz A. Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells. Sci Adv. 2019 Feb 6;5(2):eaav5590. doi: 10.1126/sciadv.aav5590. eCollection 2019 Feb. PubMed PMID: 30775443; PubMed Central PMCID: PMC6365116
  • Giurato G, Nassa G, Salvati A, Alexandrova E, Rizzo F, Nyman TA, Weisz A, Tarallo R. Quantitative mapping of RNA-mediated nuclear Estrogen Receptor β interactome in human breast cancer cells. Scientific Data. Vol. In Press. Pag.1-10 ISSN:2052-4463.
  • Alexandrova E, Nassa G, Corleone G, Buzdin A, Aliper AM, Terekhanova N, Shepelin D, Zhavoronkov A, Tamm M, Milanesi L, Miglino N, Weisz A, Borger P. Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells. Oncotarget. 2016 May 3;7(18):25150-61. doi: 10.18632/oncotarget.7209. PubMed PMID: 26863634; PubMed Central PMCID: PMC5039037.
  • Alexandrova E, Miglino N, Hashim A, Nassa G, Stellato C, Tamm M, Baty F, Brutsche M, Weisz A, Borger P. Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic patients. J Allergy Clin Immunol. 2016 Jan;137(1):58-67. doi: 10.1016/j.jaci.2015.05.031. Epub 2015 Jul 3. PubMed PMID: 26148798.
  • Stellato C, Nassa G, Tarallo R, Giurato G, Ravo M, Rizzo F, Marchese G, Alexandrova E, Cordella A, Baumann M, Nyman T, Weisz A, Ambrosino C. Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells. Proteomics. 2015 Jun;15(11):1801-7. doi: 10.1002/pmic.201400404. Epub 2015 Mar 18. PubMed PMID: 25604459.
  • Ravo M, Cordella A, Rinaldi A, Bruno G, Alexandrova E, Saggese P, Nassa G, Giurato G, Tarallo R, Marchese G, Rizzo F, Stellato C, Biancardi R, Troisi J, Di Spiezio Sardo A, Zullo F, Weisz A, Guida M. Small non-coding RNA deregulation in endometrial carcinogenesis. Submitted.2015 Mar 10;6(7):4677-91. PubMed PMID: 25686835; PubMed Central PMCID: PMC4467107.
  • Alexandrova E, Olovnikov I, Malakhova G, Zabolotneva A, Suntsova M, Dmitriev S, Buzdin A. Sense transcripts originated from an internal part of the human retrotransposon LINE-1 5' UTR. Gene. 2012 Dec 10;511(1):46-53. doi: 10.1016/j.gene.2012.09.026. Epub 2012 Sep 13. PubMed PMID: 22982412.
  • Buzdin A, Suntsova M, Bantysh O, Aleksandrova E, Zabolotneva A, Gogvadze E, and Gaifullin N. Recent inserts of transposable elements affect structure and functions of human genome. Chapter #23 (p. 269-296) in book «Radiobiology and environmental security», eds. C.E. Mothersill, V. Korogodina and C.B. Seymour. Springer, 2012 ISBN 978-94-007-1999-6 (PB) ISBN 978-94-007-1938-5 (HB) ISBN 978-94-007-1939-2 (e-book) DOI 10.1007/978-94-007-1939-2
  • Buzdin A, Kovalskaya-Alexandrova E, Gogvadze E, Sverdlov E. At least 50% of human-specific HERV-K (HML-2) long terminal repeats serve in vivo as active promoters for host nonrepetitive DNA transcription. J Virol. 2006 Nov;80(21):10752-62. PubMed PMID: 17041225; PubMed Central PMCID: PMC1641792.
  • Buzdin A, Kovalskaya-Alexandrova E, Gogvadze E, Sverdlov E. GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeats. Nucleic Acids Res. 2006 May 12;34(9):e67. PubMed PMID: 16698959; PubMed Central PMCID: PMC3303178.
  • Kovalskaya E, Buzdin A, Gogvadze E, Vinogradova T, Sverdlov E. Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions. Virology. 2006 Mar 15;346(2):373-8. Epub 2005 Dec 7. PubMed PMID: 16337666.
  • Chalaya T, Gogvadze E, Buzdin A, Kovalskaya E, Sverdlov ED. Improving specificity of DNA hybridization-based methods. Nucleic Acids Res. 2004 Sep 15;32(16):e130. PubMed PMID: 15371554; PubMed Central PMCID: PMC519126.